血清肝细胞生长因子水平与乳腺癌转移的关系

Significance of Serum Concentration of Hepatocyte Growth Factor in Patients with Metastatic Breast Cancer

目的:研究血清肝细胞生长因子(hepatocytegrowthfactory,HGF)与乳腺癌转移的关系。方法:应用双抗体夹心ELISA方法检测80例术后复发转移乳腺癌患者,50例术后无复发乳腺癌患者和20例献血员的血清肝细胞生长因子水平。结果:术后复发转移组血清HGF水平(0.90±0.52ng/ml)显著高于无复发组(0.38±0.30ng/ml;P<0.01)和正常对照组(0.22±0.36ng/ml;P<0.01)。肝转移组患者血清HGF水平(1.25±0.57ng/ml)显著高于其它转移组(0.78±0.48ng/ml;P<0.01)。多处转移组血清HGF水平(1.10±0.66ng/ml)显著高于其它转移组(0.78±0.48ng/ml;P<0.05)。结论:血清HGF水平与乳腺癌肝转移和多处转移发生密切相关。

Objective:To study the relationship between serum concentration of hepatocyte growth factor(HGF)and metastasis of breast cancer.Method:Serum HGF levels were determined in80patients with postoperatively metastatic breast cancer,50patients with postoperatively non-metastatic breast cancer,and20routine controls by using ELISA method.Result:Serum HGF level was significantly higher in recurrent group than in groups of non-metastasis and normal con-trols(P<0.01).Significantly higher level of serum HGF was observed in patients with liver metas-ta sis of breast cancer compared with those with other metastasis (P<0.01).Serum HGF level was sig nificantly higher in patients with multiple metastatic sites than in patients with other lesions(P<0.05).Conclusion:There was a closed relationship between serum HGF levels and liver metas-ta sis,multiple metastasis of breast cancer.