雌性山羊卵巢切除及用药(WX630)对其趾骨动态力学性能影响研究

Dynamic Mechanical Properties of the Phalanxes of Goats After Ovariectomy and Then Treated by WX630

研究了雌性山羊切除双侧卵巢前后,在不同的时间和喂养条件下其趾骨的生物力学性能变化情况。2岁左右的成都雌性山羊,体重(28±3)kg,随机分为对照组、假手术组、双侧卵巢切除OVX0.5年组、OVX1年组、OVX1.5年组、OVX0.5年+用药WX6300.5年组、OVX0.5年+用药WX6301年组。手术后取出山羊趾骨进行几何参数、骨密度测定和动态压缩力学试验。结果表明:所有OVX组的密度、动态弹性模量、破坏强度、比能均低于对照组和假手术组;OVX后,使用WX630使趾骨密度、弹性模量、破坏强度、比能有明显的提高。试验还表明,假手术对山羊趾骨的密度、动态弹性模量、破坏强度、比能没有明显的影响。试验结果初步认定,采用切除雌性山羊双侧卵巢的方法是研究骨质疏松病症的一种有效的动物模型,WX630可能是一种防治骨质疏松的有效药物。

To study the effects of ovariectomy and the treatment of the medical WX630 on bone, 35 goats about 2 years old weight (28±3)?kg from Chengdu were divided into 7 groups: control,sham,(ovariectomy)OVX 0.5 year,OVX 1 year,OVX 1.5 year,OVX 0.5 year and then treaded by WX630 for 0.5 year,1 year. Then the middle section of phalanxes about 30?mm long were taken out to test its densities by the principal of Archimedes and then the dynamic mechanical properties were tested on Hopkinson bar . The results showed that the densities,dynamical elasticity models,the strength and the energy consumption per unit volume of the phalanxes of the goats decrease obviously after ovariectomy .After OVX 0.5 year and then treated by WX630 0.5 year or 1 year all the parameter of the phalanxes become better and better, 0.5 year latter the density have no difference with the control group, 1 year latter both the density and the strength have no difference with the control group. WX630 may be a medical to treat the osteoporosis. 