产后抑郁症患者血浆孤啡肽及5-羟色胺水平变化的意义

Changes and significance of orphanin and serotonin in patients with postpartum depression

目的 探讨产后抑郁症患者血浆中孤啡肽及 5 羟色胺水平变化与产后抑郁症发病的关系。方法 采用放射免疫法测定 2 5例正常产妇 (对照组 )及 2 1例产后抑郁症患者 (抑郁症组 )血浆中孤啡肽及 5 羟色胺水平。结果 (1)抑郁症组血浆孤啡肽水平为 (2 8 5± 5 8)ng/L ,对照组血浆孤啡肽水平为 (10 4± 3 7)ng/L。抑郁症组血浆孤啡肽水平显著高于正常组 ,两组比较 ,差异有极显著性 (P <0 0 1)。 (2 )抑郁症组血浆 5 羟色胺水平为 (1 0± 0 3) μmol/L ,对照组为 (1 4± 0 4 ) μmol/L。抑郁症组血浆 5 羟色胺水平低于对照组 ,两组比较 ,差异有显著性 (P <0 0 5 )。 (3)抑郁症组血浆孤啡肽水平与 5 羟色胺水平呈显著负相关 (r=- 0 5 71,P <0 0 5 )。结论 产后抑郁症患者血浆孤啡肽水平变化与产后抑郁症的发生密切相关。

Objective To study the changes of orphanin (OFQ) and serotonin(5-HT) in the patients with postpartum depression(PPD). Methods Twenty one patients with postpartum depression (PPD group) and 25 healthy lying-in women(control group) were studied .The concentrations of plasma OFQ were measured by radioimmunoassay. The levels of 5-HT were measured with high-pressure liquid chromatography with electrochemical detector. Results (1)The levels of plasma OFQ in PPD group were(28.5±5.8)ng/L,in control group, the levels of OFQ was (10.4±3.7)ng/L, the levels of OFQ in PPD group were significantly higher than that in the control group( P <0.01).(2)The levels of plasma 5-HT in PPD group and control group were(1.0±0.3)μmol/L and (1.4±0.4)μmol/L respectively, the levels of 5-HT in PPD group decreased significantly ( P <0.05).(3)In the PPD group , there was a significant negative correlation between the OFQ and 5-HT level( P <0.05).Conclusion The PPD was associated with OFQ and 5-HT , the changes of OFQ levels may play an important role in the pathogenesis of the PPD.