邻醌式同系物的DSC研究

STUDY ON O-QUINONOID FORM HOMOLOGUES BY DSC

丹参(Salvia miltirrohiza)和红根草(S.Prionitis)均含有治疗冠心病有效成分—丹参酮Ⅱ-A等二萜醌类化合物,它们的扩冠作用,抑制血小板聚集,抑菌等活性常与该类化合物的结构、晶型、极性、溶解度、熔点有密切的相关性,如前报所述A环为脂环的化合物其熔化热低于芳环的化合物.丹参中的丹参醌Ⅱ-A(1),丹参醌Ⅱ-B(2)和红根草邻醌(3),其抗菌和抗肿瘤活性强度是3>2>1,为探究其晶型结构与药效的内在联系。

This paper presents the study on thermodynamic characteristics of phase transiti-ons for tanshinone Ⅱ-A, tanshinone Ⅱ-B and saprorthoquinone (hereafter abbrevia-ted to 1,2 and 3 respectively) by Differential Scanning Calorimetry (DSC). The re-lationships of their molecular structures with thermodynamic parameters were discussed.The experimental results obtained are listed in Table 2. The differences of nominated compounds for their melting points, melting enth-alpies and melting entropies are as follows: T_m^1>T_m^3, ΔH_m^1>ΔH_m^3, ΔS_m^1=ΔS_m^3; T_m^1>T_m^2, ΔH_m^1>ΔH_m^2, ΔS_m^1>ΔS_m^2.