阿米卡星在老年呼吸系统感染患者体内的药动学研究

The Pharmacokinetics Study of Amikacin in Old Patients with Respiratory System Infections

目的 :研究阿米卡星 (AMK)在老年呼吸系统感染患者体内的药动学 ,为临床合理用药提供依据。方法 :用荧光偏振免疫方法测定药物的血药浓度。结果 :AMK的药 -时曲线符合二房室模型。AMK在健康志愿者和老年呼吸系统感染患者体内的T1/2β 分别为 (2 14±0 81)h、(4 32±1 05)h ;AUC分别为 (70 68±26 47) (mg·h)/L、(101 83±9 73) (mg·h)/L。结论

OBJECTIVE:The pharmaceutics of Amikacin(AMK)in old patients with respiratory system infections was studied to provide a basis for clinical use.METHODS:Fluorescence polarizing immunoassay method was employed to detect blood drug concentration.RESULTS:The blood concentration-time curve of AMK fitted in with the two-compartment modˉel.The T 1/2β and AUC of AMK in the healthy volunteers and old patients with respiratory system infections were(2.14±0.81)h and(4.32±1.05)h(P<0.01),and(70.68±26.47)(mg·h)/L and(101.83±9.73)(mg·h)/L respectively(P<0.01).CONCLU SION:The pharmacokinetic process of AMK in the old patients with respiratory system infections is obviously different from that in the healthy volunteers.