帕罗西汀治疗强迫症的随机双盲对照研究

Study of Paroxetin in treatment of Obsessive-Compulsive Disorder with random double blind procedure control

目的 比较帕罗西汀和氯咪帕明治疗强迫症的临床疗效和副反应。方法 以CCMD - 2R作为诊断强迫症的入组标准 ,用Yale -Brown强迫量表 (Y -BOCS) ,汉密顿抑郁量表 (HAMD)和副反应量表(TESS) ,评定临床疗效和副反应 ;采用随机双盲双模拟的方法 ,对 5 8例入组患者应用帕罗西汀和氯咪帕明进行 10周的对照治疗。结果 帕罗西汀与氯咪帕明临床疗效相当 (P >0 .0 5 )。帕罗西汀组副反应较氯咪帕明少。结论 帕罗西汀治疗强迫症疗效好 ,副反应少。

Objective:To compare the clinical effect and side effect between Paroxetine and chlornmipromine in treatment of Obsessive-Compulsive Disorder.Methods:According to CCMD-2R,58 patients with Obsessive-Compulsive Disorder diagnosed were treated by Paroxetine and chlornmiprominer for 10 weeks in our study.The clinical effect and side effect were evaluated by measurement of Yale-Brown Obsessive-Compulsive rating Scale (Y-BOCS),Hamilton depression rating scale(HAMD) and Treatment Emergent symptom Scale (TESS).Result:Paroxetine were effective in treatment of Obsessive-Compulsive Disorder with less adverse effect in comparison with chlornmiprominer.Conclusion:Paroxetine is an effective and less side effect drug in treatment of Obsessive-Compulsive disorder.