sIL-2R和16在肝移植术后早期急性排斥和细菌感染中的诊断价值(英文)

Significance of sIL-2R and IL-6 in the diagnosis of acute rejection and bacterial infection during liver transplantation

目的 探讨血浆和胆汁中可溶性白细胞介素 2受体 (sIL - 2R)和白细胞介素 6 (IL - 6 )对于肝移植术后早期急性排斥和细菌感染的诊断价值。方法 对 2 0例肝移植患者进行研究 ,测定围手术期血浆及胆汁中的sIL - 2R和IL - 6。结果 急性排斥时 ,血浆sIL - 2R在病理诊断前就可升高 ,胆汁IL - 6在 4例患者中 3例日升幅大于 4 5 0pg/ml;细菌感染时 ,血浆IL - 6可明显升高 ;胆汁sIL - 2R在急性排斥和细菌感染时均无明显变化。结论 sIL - 2R和IL - 6对于肝移植术后早期急性排斥和细菌感染的诊断有一定的价值。

Objective:To investigate the significance of soluble interleukin-2 receptor (sIL-2R) and interleukin-6 (IL-6) in plasma and bile in the diagnosis of acute rejection and bacterial infection in the early stage after liver transplantation.Methods: 20 patients undergoing orthotopic liver transplantation were included in our study. SIL-2R and IL-6 levels in plasma and bile were measured perioperatively by enzyme-linked immunoadsorbent assay.Results: Plasma sIL-2R elevated prior to the pathological diagnosis of acute rejection and daily increase of IL-6 in bile was more than 450 pg/ml ,which was seen in 3 of 4 patients prior to or at the onset of acute rejection. IL-6 in plasma increased significantly when bacterial infection occurred, while slL-2R in bile correlated with neither acute rejection nor bacterial infection.Conclusions: Measurements of sIL-2R and IL-6 may be useful in diagnosing acute rejection and bacterial injection during liver transplantation.