常规机械通气治疗兔海水淹溺型肺水肿

Therapeutic Effect of Conventional Mechanical Ventilation on Pulmonary Edema after Seawater Drowning in Rabbits

目的 观察常规机械通气治疗兔海水型肺水肿。方法 应用常规机械通气对14只海水型肺水肿新西兰大白兔进行救治,着重观察治疗后血气分析、肺损伤指标、病理学的改善情况,并观察部分呼吸动力学、血流动力学指标。结果 常规机械通气治疗后海水型肺水肿兔血氧分压、血氧饱和度、二氧化碳分压均较未治疗组有明显改善(P<0.01),呼吸动力学、血流动力学异常得到一定程度纠正,通气治疗后肺损伤程度减轻。结论 常规机械通气治疗海水型肺水肿时低氧血症取得满意效果,是一种有效的治疗海水型肺水肿的通气方式。

Objective To observe the therapeutical effect of conventional mechanical ventilation (CMV) on pulmonary edema after seawater drowning in rabbits. Methods Fourteen seawater drawing induced pulmonary edema New Zealand rabbits models were randomly assigned to received CMV treatment. Blood gas analysis, pulmodynamic, hemodynamics status and tumor necrosis factor (TNFα) extracted from serum were monitored at various time point. After 3 hours ventilation, 7 rabbits of each groups were killed to gain lung tissues for pathology examination and lung lavage fluid was analyzed for the count leukocyte. Results PaO2 and SO2 were significandy increased after the use of ventilation in pulmonary edema rabbits models (P <0.01). Pulmodynamics and hemodynamics were ameliorated. The results of TNFa monitor and the count of leukocytes show that the degree of lung injury were relieved. Conclusion Our study showed CMV were significantly improve hypoxemia of PE-SWD rabbits models, and relieved the degree of lung injury to some extend.