负性生活事件对抑郁症患者血清细胞因子水平的影响

Effects of negative life events on serum cytokine levels in patients with depression

目的 探讨负性生活事件对抑郁症患者血清细胞因子水平的影响。方法 采用酶联免疫吸附法 (EL SIA)对有负性生活事件诱因的抑郁症患者 2 3例、无诱因的抑郁症患者 2 9例和 2 9名正常人的血清白介素 2 (IL 2 )、可溶性白介素 2受体 (sIL 2R)、白介素 10 (IL 10 )和白介素 12 (IL 12 )水平进行检测。结果 3组间IL 2、sIL 2R及IL 12水平存在显著性差异 ,而IL 10则 3组间无显著性差异 ,有负性生活事件诱因组IL 2及sIL 2R水平明显低于无诱因组和对照组 (P <0 0 1) ;有诱因组其负性生活事件对患者心理活动影响的严重程度与IL 2和sIL 2R水平呈负相关(P <0 0 5 )。结论 负性生活事件对抑郁症患者的细胞免疫激活系统有抑制作用 ,IL 2可能是起主要的中介作用。

Objective To explore the effects of negative life events on serum cytokine levels in patients with depression. Methods ELSIA was used to evaluate the levels of serum interleukin-2 (IL-2), soluble interleukin-2 receptor (sIL-2R), interleukin-10 (IL-10) and interleukin-12 (IL-12) in 23 patients with negative life events induced depression, 29 patients with non-life events induced depression and 29 normal controls. Results The levels of serum interleukin-2 (IL-2) and soluble interleukin-2 receptor (sIL-2R) were lower in negative life event group than non life event group and control group, the differences in IL-10 levels were not obvious in three groups. Affective of negative life events on patients' psychology had negative correlation with the levels of IL-2 and sIL-2R. Conclusion Negative life events have suppressing action on cellular immunity activating system and IL-2 may play a mediated role.