茵陈提取液对实验性动物肝损伤的作用

Protective Effects of Water Extract from Artemisia Capillaris Thunb on Experimental Hepatic Injury

目的 研究茵陈提取液对实验性肝损伤的作用。 方法 用茵陈提取液连续给小鼠灌胃 7d后 ,采用四氯化碳 (CCL4 )腹腔内注射造成小鼠急性肝损伤 ,造型 2 0h后摘除眼球取血 ,测ALT、AST、ALP、TP、G、A等指标 :给大鼠每周二次皮下注射 10 %CCL4油液 0 .5ml/ 10 0g ,造成慢性肝损伤 ,于中毒第三个月初起开始 ,每日用茵陈提取液连续给大鼠灌胃一个月 ,于末次给药 2 4h眶静脉取血 ,分离血清 ,AT、AST、总蛋白、白蛋白、白蛋白 /球蛋白 (A/G)等指示。 结果 CCL4造成小鼠急性肝脏损伤 ,出现明显肝功能异常 ,茵陈提取液治疗组小鼠各项指标较CCL4模型组均有所降低 ,但差异无显著性意义 (P >0 .0 5 ) ;在CCL4所致大鼠慢性肝损伤模型中 ,茵陈提取液治疗组可显著地降低大鼠由CCL4造成的AST活性升高 ,与模型组比较 ,P <0 .0 1。 结论 茵陈提取液对CCL4所致大鼠慢性肝损伤有较好的治疗作用 ,但对CCL4造成小鼠急性肝伤模型没有保护作用。

Objective To investigate the protective effects of the water extract from Artemisia capillaris Thunb on carbon tetracholride(CCL4)-induced experimental hepatic injury in mice and rat.Methods The model of hepatic injury was induced by CCL4.The biochemical indexes of serum ALT?AST?ALP?TP?G?A?A/G were determined.Results the water extract from Artemisia Capillaris Yhunb significantly inhibited the rising of serum ALT,AST induced CCL4.Conclusion the water extract from Artemisia Capillaris Thunb had significant protective effects on CCL4-induced experimental hepatic injury.