银杏黄酮苷治疗血管性痴呆43例

Treatment of 43 Cases of Vascular Dementia with Ginkgo Flavone Glycoside

目的 :观察银杏黄酮苷治疗血管性痴呆的疗效及安全性。方法 :治疗组 43例 ,给予银杏黄酮苷 70mg ,加入 0 .9%氯化钠溶液 3 0 0mL ,静脉滴注 ,qd ,15d为 1个疗程 ,然后口服银杏黄酮苷 80mg,tid ,连用 75d。对照组 43例 ,给予吡拉西坦注射液 0 .8g加入 0 .9%氯化钠注射液 3 0 0mL ,静脉滴注 ,qd ,15d为 1个疗程 ,然后口服吡拉西坦 0 .8g ,tid ,连服 75d。 3个月后两组再重复静脉用药 (同剂量 ,同疗程 ) ,两组疗程均为 6个月。结果 :治疗 3和 6个月后 ,治疗组MMSE评分明显优于对照组 (P <0 .0 1) ,社会功能活动量表 (FAQ)评分治疗 6个月后明显优于对照组 (P <0 .0 1)。结论 :银杏黄酮苷能持续改善血管性痴呆患者的认知及社会功能 ,能延缓痴呆的发展 。

Objective:To look into the therapeutic effec ti veness and safeness of ginkgo flavone glycoside in the treatment of vascular dem entia. Methods:86 patients with vascular dementia were randomly divided into two equal groups. Patients of the treatment group were given each 70 mg of ginkgo flavone glycoside in 300 mL of 0.9% sodium chloride solution adm inistered by IV instillation q.d. for 15 consecutive days as a course of treatme nt, followed by 80 mg of ginkgo flavone glycoside PO t.i.d.. for 75 consecutive days, Patients of the control group were given each 0.8 g of piracatam injection in 300 mL of 0.9% sodium chloride solution administered by IV instillation q.d. for 15 consecutive days as a course of treatment followed by 0.8 g of piracetam PO t.i.d. for 75 days. 3 months later, patients of both groups were subjected t o a second course of IV medication in the same doses of the drugs and the same d uration of time as in the first course. The time of treatment in both groups las ted 6 months. The state of noopsyche and social functions in patients of both gr oups was tested with the MMSE and FAQ capacity tables respectively, before as we ll as 3 and 6 months after the beginning of the treatment. Results:The score of MMSE in patients of the treatment g roup 3 and 6 month after the beginning of the treatment was evidently superior t o that in patients of the control group (P<0.01). 6 months after the beginn ing of the treatment, the score of FAQ was strikingly superior to that in patien ts of the control group (P<0.01). Conclusion:Ginkgo flavone glycoside was shown to cause a sustained improvement of the noopsyche and social functions and a slowdown of t he progress of the disease in patients with vascular dementia. The drug was also found to be safe and no obvious side effects were encountered.