泛昔洛韦合用α-干扰素治疗慢性乙型肝炎30例

Clinical Effect on Chronic Hepatitis B Treated by Famciclovir and Combination Fa mciclovir with INF-α

目的 :比较单用泛昔洛韦和泛昔洛韦联用α 干扰素治疗慢性乙型肝炎的临床效果。方法 :60例慢性乙型肝炎患者 ,随机分两组各 3 0例。对照组单用泛昔洛韦 50 0mg ,po ,tid ,疗程 4个月 ;治疗组在口服泛昔洛韦基础上加用α 干扰素 3 0 0万U ,im ,qod ,疗程 6个月。结果 :治疗组和对照组肝功能恢复和HBV DNA阴转率差异无显著性 (P >0 .0 5)。而对照组HBeAg阴转率 53 .3 % ,与治疗组 70 .0 %比较 ,差异有显著性 (P <0 .0 5) ,两组病例均无明显副作用。结论 :泛昔洛韦治疗慢性乙型肝炎疗效好 ,副作用少 。

Objective:To observe the therapeutic effect of only famciclovir and combination famciclovir with INF-α on chronic hepatitis. Methods:60 points were divided into two groups, one grou p of the 4th month of course treatment were treated by only famciclovir 500 mg t hree a day, the other group of combination famciclovir with INF-α 3×10 6 U e very two days for 6th month.Results:The result showed the famciclovir eliminating r ates of HBV-DNA and remission of serum ALT were close to that of combination fa mciclovir with INF-α. The negative rate of HBV-DNA was 66.7%, 70.0% respectiv ely. The differentiation between the two groups had no obviously significance( P>0.05). No obvious effect was founded.Conclusion:The result indicate the therapeutic method of only famciclovir may regulate liver of function, inhibit viral DNA and improve the therapeutic effect. Combination famciclovir with INF-α can improve the HBe Ag seroconversion rate.