P-gp在骨肉瘤组织中的表达及与LRP、bcl-2的关系

Expression of P-gp in Osteosarcoma and Correlation with the Expression of LRP、bcl-2

目的 :探讨P gp在骨肉瘤组织中的表达 ,以及与LRP、bcl 2蛋白的相关性。方法 :用免疫组化方法检测了 42例骨肉瘤组织中P gp ,LRP ,bcl 2的表达。结果 :2 9例获得平均 1年 8个月的随访 ,复发 5例 ,肺转移 16例 (其中 8例死亡 )。P gp的表达率为 3 5 71% ,与预后有关。P gp和LRP表达具有相关性 ;P gp与bcl 2的表达之间均无相关性 ;三者的表达与年龄、性别、分型及Enneking分期无关。结论 :P gp和LRP的表达是骨肉瘤多药耐药性的重要因素 ,并影响患者的预后。

Objective:To investigate the expression of P-gp in osteosarcoma and its correlation with the expression of the LRP?bcl-2 protein.Methods:The expression of P-gp,LRP and bcl-2 was investigated by SABC immunohistochemical staining in 42 patients with osteosarcom.Results:Twenty-nine cases were followed-up with the average time of 1 year and 8 months,there were 5 cases in recurrent and 16 cases in lung metastasis (8 died among them).The positive expression rate of P-gp was 35.71%,and no correlation with clinical-factor,and related with the prognosis,there was a high correlationship between P-gp and LRP expression,no relationship between P-gp and bcl-2,LRP and bcl-2 expression.Conclusion:The expression of P-gp is an important factor of exsisting multidrug resistance in osteosarcoma,and influnencing the prognosis.