温肾泄浊汤治疗慢性肾功能衰竭的临床观察

Clinical Observation of Wenshen Xiezhuo Decoction in Treating Pations with Chronic Renal Failure

目的:观察温肾泄浊汤治疗慢性肾功能衰竭(CRF)的临床疗效。方法:选择CRF脾肾阳虚、湿浊瘀阻证60例,随机分为两组。对照组30例予低蛋白饮食、控制高血压及对症治疗;治疗组30例,在对照组治疗的基础上加服温肾泄浊汤。观察治疗2个月后两组临床疗效、中医症状积分、肾功能、血钙、血磷和白蛋白的变化。结果:治疗组在显效率、总有效率、改善中医症状和肾功能、降低血磷、升高白蛋白方面优于对照组(P<0.05,P<0.01)。结论:CRF脾肾阳虚、湿浊瘀阻证患者在常规西医治疗基础上加用温肾泄浊汤疗效明显优于单纯西医治疗。

Objective:To observe curative effect of Wenshen Xiezhuo Decoction ( WSXZD) in treating pations with chronic renal failure (CRF). Methods: Sixty patients with CRF of deficienncy of spleen-Yang and kidney-Yang with damp pathogen and blood stasis symptom were randomly divided into the treated group and the control group,30 in each group. Both groups were treated with low-protein diets,controlling hypertension and symptomatic treatment. And WSXZD was given additionally to the treated group. The curative effect and the changes of integral of traditional Chinese medicine ( TCM ) symptoms, renal function, serum calcium, serum phosphorus and ALB were observed after two months. Results:The significant and total effective rate of the treated group were higher than that of the control group ( P < 0. 05 , P<0. 01). Compared with the control group, integral of TCM symptoms and the levels of serum phosphorus were decreased significantly, the levels of ALB were increased significantly, and renal function was improved significantly in the treated group ( P <0. 05,P <0. 01). Conclusion:The curative effect of conventional western medicine therapy plus WSXZD in treating pations with CRF of deficiency of spleen-Yang and kidney-Yang with damp pathogen and blood stasis symptom was significantly better than that of conventional western medicine therapy.