摘要
目的研究我国异常血红蛋白总体和在部分地区的发生率、分布和产生原因。方法应用群体遗传学研究方法对我国已经发表的有关资料和本人工作进行群体遗传学分析。结果我国异常血红蛋白平均发生率为0.337％,各省区均有分布(除西藏),发生率各省区不同,产生原因多种。结论我国异常血红蛋白有高度的分布不均一性和遗传多态性,在全国有3个高发区带,主要的影响因素有迁移、经商、通婚和基因突变等。
Objective To study the incidence, distribution and genetic polymorphism of the abnormal hemoglobin in China. Methods The population genetics were used to analyze the abnormal hemoglobin in China. Results The average incidence of the abnormal hemoglobin in China was 0.337%, There are dissimilarities of the incidence and distribution in various provinces.Conclusions There are distribution and genetic polymorphism of the abnormal hemoglobin in China.The reason that the distribution and genetic polymorphism are found in China relates to the migration, trade, intermarriage and gene mutation.
出处
《医学研究通讯》
2003年第12期12-14,共3页
Bulletin of Medical Research
基金
江苏省重点课题资助项目
