甲氨蝶呤局部注射治疗子宫腺肌病研究

Effects of MTX regional treatment in adenomyosis

目的探讨甲氨蝶呤(MTX)局部注射治疗子宫腺肌病的可行性。方法 20例子宫腺肌病的病人,每月月经干净3～5天时。在子宫病灶局部及周围注射MTX 50mg,连续6个月。治疗前、后行子宫附件阴式B超检查、子宫病灶局部穿刺活检及血常规、肝肾功能、性激素检查,同时观察临床症状。结果治疗前与与MIX治疗后3个月比较B超测子宫长度、子宫厚度、子宫后壁厚度有显著性差异(P<0.05);治疗后6个月比较子宫长度有非常显著性差异(P<0.01),子宫厚度、子宫后壁厚度减少有显著性差异(P<0.05)。治疗前与治疗后Hb、WBC、PC、ALT、BUN、PSH、LH、E、T、P无显著性差异(P>0.05),仅PRL在治疗后3个月较治疗前有显著性差异(P<0.05)。结论局部应用MTX治疗子宫腺肌病将是一个有发展前景的治疗手段。

Objective To study the effect in local use of Methobexate (MIX) on adenomyoeis. Methods 20 patients of adenomyosis were injected MIX 50mg per Mouth after menstruation.We measured size of uterus on adenomyosis by ultrasonography, Hb, WBC, PC, ALT, BUN, FSH, LH, E, T, P, PRL and investigated signs before after treatment.Results The effect after treatment was better than before treatment in length of uterus, thickness of uterus.Conclusions The effect in local use of MIX of treatment on ndenomyosis is future treatment.