银杏达莫注射液对急性心肌梗死血小板聚集的影响

The Protective Effect of Ginkgo Leaf Extract and Dipyridamole Injection on the Rate of Platelet Aggregation in Patients with Acute Myocardial Infarction

目的 :探讨银杏达莫注射液对急性心肌梗死 (AMI)溶栓后血小板聚集的影响。方法 :将AMI溶栓治疗判为临床再通者 64例分为对照组 ( 3 2例 )及银杏达莫组 ( 3 2例 )。银杏达莫组在对照组基础上予以银杏达莫静脉输注。统计 2h内心电图ST段抬高指数(∑STI)下降≥ 5 0 %率与ST段完全回落率。测量溶栓前即刻及溶栓后 2h、10h血小板聚集率。结果 :银杏达莫组与对照组比较 :①心电图∑STI下降≥ 5 0 %率、ST段完全回落率均显著提高 ( 96.9%∶71.8% ,P <0 .0 5 ;87.5 %∶5 3 .1% ,P <0 .0 5 ) ;②溶栓后2h两组血小板聚集率银杏达莫组明显低于对照组 [( 3 1±18) %∶ ( 4 5± 2 2 ) % ,P <0 .0 1] ,10h两组相同 [( 15±7) %∶( 13± 6) % ,P >0 .0 5 ]。结论 :银杏达莫液能通过迅速抑制血小板功能 ,减轻心肌再灌注损伤。

Objective:To investigate the effect and the mechanism of Ginkgo Leaf Extract and Dipyridamole Injection on the rate of platelet aggregation in patients with Acute Myocardial Infarction(AMI). Methods:The patiens with the first AMI were divided into two groups at random. One was treated with thrombolysis,and the other was given intravenous injection of Ginkgo Leaf Extract and Dipyridamole before thrombtherapy. To record the 18-lead elctrocardiogram before and two hours and twenty-four hours after thrombolysis, and test the platelet aggregation before and two hours and ten hours after thrombolysis. Results:①The cases of ∑STI resolution≥50% and ST-segment recovery completely in Ginkgo Leaf Extract and Dipyridamole group were more than that in control group significantly (96.9% vs 71.8%, P<0.05; 87.5% vs 53.1%, P<0.05); ②The rate of platelet aggregation two hours after thrombolysis in Ginkgo Leaf Extract and Dipyridamole group were lower than in control group significantly[(31±18)% vs (45±22)%, P<0.01] and those ten hours after thrombolysis were similar [(15±7)% vs (13±6)%, P>0.05]. Conclusion:Intravenous injection of Ginkgo Leaf Extract and Dipyridamole before thrombolysis has protective effects microcirculation reperfusion and can decress the infarction size.