阿托伐他汀和辛伐他汀对高胆固醇血症的调脂作用比较研究

Comparison of the effects of atorvastatin with simvastatin on lipid profile modification in patients with hypercholestrolemia

目的 比较阿托伐他汀与辛伐他汀对高胆固醇血症的调脂作用。方法 将高脂血症患者 4 6例随机分为阿托伐他汀组和辛伐他汀组 ,服药前及服药后 4、8周测定血脂。结果 (1 )服药 4周后两组总胆固醇 (TC)、低密度脂蛋白胆固醇 (LDL C)及甘油三酯 (TG)均明显降低 (P <0 .0 1 ) ,两组作用相似。 (2 )服药 4周后 ,阿托伐他汀组Lp(a)水平降低了 2 9.3% ,辛伐他汀组Lp(a)水平降低了 2 0 .2 6 %。 (3)服药 8周后Lp(a)水平进一步下降 ,与治疗前相比 ,阿托伐他汀组Lp(a)水平下降了 34.79% ,辛伐他汀组下降了 2 3.5 4 % ,其他指标与 4周时比较无明显差异 (P >0 .0 5 )。结论 阿托伐他汀能显著降低高胆固醇血症患者血清TC、LDL C及TG ,并且其作用与辛伐他汀相似 ,在降低Lp(a)上 。

Objective To study the effects of atorvastatin on lipid profile modification in patients with hypercholestrolemia and to compare it with simvastatin.Methods Fourty six patitents with hypercholestrolemia were randomized into a treatment group( n =23,atorvastatin 10mg/d qn)and a control group ( n =23,simvastatin 10mg/d qn).Blood lipid levels were determined prior to lipid lowering treatment and at the end of 4 and 8week treatment respectively.Result (1) The effects of atorvastatin in lowering serum total cholesterol(TC) and low density lipoprotein cholesterol (LDL C) and triglyceride (TG) levels were the same as simvastatin.(2) Atorvastatin decreased serum Lp(a) levels by 29.30% after 4 weeks( P <0.01) and by 20.26% in the control group.(3)Atorvastatin decreased serum Lp(a) levels by 34.79% after 8weeks( P <0.05) and by 23.54% in the control group.TC,LDL C and TG were not decreased significantly.The same effects of both simvastatin and simvastatin on serum TC,LDL C and TG were observed after 4 weeks or 8 weeks.Conclusion The effects of simvastatin on serum TC,LDL C and TG were the same as simvastatin.Lp(a) lowering effects were superior to that of simvastatin.