血清降钙素原及C-反应蛋白在诊断老年脓毒症中的应用

The application of serum procalcitonin and C-reactive protein in the diagnosis of sepsis of old patients.

目的 比较血清降钙素原 (PCT)及C 反应蛋白 (CRP)在老年脓毒症诊断中的应用价值。方法 以最终临床诊断为金标准 ,计算取不同浓度做截断点时的灵敏度、特异度及尤登指数。结果 C 反应蛋白的灵敏度及诊断准确度高于PCT ,而特异度则低于后者。结论 对老年人仍可把C 反应蛋白作为脓毒症的辅助诊断指标 ,必要时可以检测PCT以提高诊断的特异度。

Objective To compare the value of procalcitonin(PCT) and C-reactive protein(CRP) in the diagnosis of sepsis of old patients. Methods The sensitivity, specificity and Youden's index were calculated according to different levels of cutoff score, in response to the final clinical diagnosis as golden standard. Results CRP had a higher sensitivity and accuracy but lower specificity. Conclusion CRP can be used as a marker of sepsis in the elderly and necessary determination of PCT can improve the specificity of diagnosis.