甲孕酮合并化疗改善晚期肺癌患者的生活质量

Combination of chemotherapy with medroxyprogesterone acetate improves quality of life in patients with advanced lung cancer

目的观察晚期肺癌患者服用甲孕酮后化疗毒副反应改善情况,及止痛和促进蛋白同化作用。方法130例接受化疗的晚期肺癌患者采用单盲法随即分成单用化疗组及化疗+甲孕酮组。结果在化疗+甲孕酮组治疗的160个周期中43.1％患者食量增加,45％体重增长,平均每周期体重增加0.74±1.56 kg,血浆白蛋白升高1.2±2.9g/L。88.1％患者疼痛减轻,28.1％ECOG评分改善。化疗的毒副反应按WHO抗癌药物急性毒性分级标准,Ⅱ度以上白细胞下降发生率为33.8％,血红蛋白下降15.6％,胃肠道反应18.1％,平均恢复时间分别为6.4±4.6、5.3±4.1及1.89±1.2 d。以上各项指标与单用化疗组相比差异均有显著性。结论 甲孕酮如能正确合理地用于晚期癌症的治疗,可以全面改善化疗期间癌症患者的生活质量。

Objective To investigate the effect of medroxyprogesterone acetate(MPA) on anorexia,weight loss, decrease in life quality, myelosuppression as well as nausea and vomiting caused by chemotherapy, also to observe the effect of alleviating cancerous pain and promoting albumin assimilation. Methods One hundred-thirty patients with advanced lung carcinoma were divides into two groups: chemotherapy alone and chemotherapy plus MPA. Results The chemotherapy + MPA group showed increase in food intake (43.13 %), weight gain (45 %) by 0.74 ± 1.56 kg per treatment cycle, rise of blood albumin to 1.2±2.9 g/L in average, improvement of ECOG in 28.1 % and abatement of cancerous pain in 88.1 % According to the WHO criteria of side effect of chemotherapy, there were leukopenia grade Ⅱ or more severe(WBC decreased by 33.8%) .decrease in hemoglobin by 15.6% and gastro-intestinal reaction in 18.1% .The mean recovery time in two groups was 6.4 ±4.6 days and 1.89± 1.2 days respectively. As compared with the chemotherapy alone group, the differences in above indices were statistically significant. Conclusion Reasonable use of MPA can improve the life quality of patients with advanced lung cancer treated with chemotherapy.