结肠癌术后吗啡罗哌卡因硬膜外镇痛效果的观察

Postoperative Epidural Analgesia with Ropivacaine and Morphine after Colectomy

目的:观察吗啡与罗哌卡因配伍用于结肠癌术后硬膜外镇痛的有效性和安全性。方法:选择结肠癌手术患者75例,随机分为三组(n=25):0.1%吗啡组(Ⅰ组)、0.15%吗啡组(Ⅱ组)和0.1%吗啡加0.2%罗哌卡因组(Ⅲ组),持续注入4ml/h,术后镇痛48h。采用视觉模拟评分法(VAS法)估计镇痛效果。结果:Ⅲ组镇痛效果明显好于其它两组(P<0.05),对下肢肌力无影响,排气时间明显提前。结论:0.2%罗哌卡因与0.1%吗啡配伍用于结肠癌术后镇痛效果确切、安全。

Objective:To observe the efficiency and safety of epidural analgesia with ropi-vacaine and morphine after Colectomy.Methods:75patients undergoing electiv e Colectomy were randomly entered into three groups(n=25):morphine0.1 %group(Ⅰ);morphine0.15%group(Ⅱ)and morphine0.1%with ropivacaine 0.2%group(Ⅲ).The continous infusion rate was4ml/h.The analgesia effic iency was evaluated with visual analog scale(VAS).Results:Comparing to the o ther two groups the VAS score was significantly lower(P<0.05)and the mus cle of lower limbs had no obvious influence in groupⅢ.The exhaust time of gro upⅢwas earlier than groupⅠand groupⅡ.Conclution:The combination of ropivaca ine0.2%and morphine0.1%may be safe and effective for epidural analgesia .