摘要
To study the clinical effects of Da Ding Feng Zhu (大定风珠) Decoction on liver fibrosis. 56 patients withliver fibrosis due to chronic hepatitis B were randomly divided into a treatment group (30 cases treatedwith Da Ding Feng Zhu Decoction) and a control group (26 cases treated with colchicine). The serumlevels of hyaluronic acid (HA), procollagen Ⅲ (PC-Ⅲ), Ⅳ collagen (Ⅳ-C) and Laminin (LN) of thepatients were determined, compared and analyzed before treatment and after 3-month treatment in the twogroups. The results showed that in the treatment group, the levels of HA, PC-Ⅲ, Ⅳ-C and LN after3-month treatment were significantly lowered as compared to that before treatment (P＜0.01). In thecontrol group, only the HA level was obviously lowered (P＜0.05). There was an significant difference(P＜0.05) in PC-Ⅲ and Ⅳ-C and a very significant difference (P＜0.01) in HA after treatment between thetwo groups. It is therefore concluded that Da Ding Feng Zhu Decoction can lower serum indexes of liverfibrosis.
To study the clinical effects of Da Ding Feng Zhu (大定风珠) Decoction on liver fibrosis. 56 patients with liver fibrosis due to chronic hepatitis B were randomly divided into a treatment group (30 cases treated with Da Ding Feng Zhu Decoction) and a control group (26 cases treated with colchicine). The serum levels of hyaluronic acid (HA), procollagen Ⅲ (PC-Ⅲ), Ⅳ collagen (Ⅳ-C) and Laminin (LN) of the patients were determined, compared and analyzed before treatment and after 3-month treatment in the two groups. The results showed that in the treatment group, the levels of HA, PC-Ⅲ, Ⅳ-C and LN after 3-month treatment were significantly lowered as compared to that before treatment (P<0.01). In the control group, only the HA level was obviously lowered (P<0.05). There was an significant difference (P<0.05) in PC-Ⅲ and Ⅳ-C and a very significant difference (P<0.01) in HA after treatment between the two groups. It is therefore concluded that Da Ding Feng Zhu Decoction can lower serum indexes of liver fibrosis.
关键词
肝纤维化
中医药疗法
大定风珠
细胞因子
药理作用
乙型肝炎病毒
Phytotherapy
Adult
Collagen Type III
Collagen Type IV
Drug Combinations
Drugs, Chinese Herbal
Female
Hepatitis B
Humans
Hyaluronic Acid
Laminin
Liver Cirrhosis
Male
Middle Aged
