慢性乙型肝炎患者外周血淋巴细胞上CXCR3表达的初步观察

Preliminary observation of CXCR3 expression on peripheral blood lymphocytes from patients with chronic hepatitis B infection

目的 :探讨趋化性细胞因子受体CXCR3在慢性乙型肝炎症发生机制中的作用。方法 :采用流式细胞术 ,检测炎症活动程度不同患者外周血淋巴细胞表面CXCR3的表达 ,及其在CD4 + 和CD8+ T细胞上的分布。结果 :慢性乙肝患者外周血CXCR3+ 淋巴细胞和单核细胞明显增多 ,以CXCR3+ CD8+ T细胞的增加更明显。结论 :趋化因子受体CXCR3与其配体的相互作用 。

AIM: To explore the role of chemokine receptor CXCR3 in pathogenesis of chronic hepatitis B. METHODS: The expression of CXCR3 on peripheral blood lymphocytes from chronic hepatitis B patients with various degrees of inflammation was detected, and the distributions of CXCR3 on CD4 + and CD8 + T lymphocytes were also evaluated by FACS. RESULTS: As compared with healthy controls, the percentages of CXCR3 + lymphocytes, monocytes and CD8 + T cells were increased significantly in chronic hepatitis B patients. CONCLUSION: Above data suggest that chemokine receptor CXCR3 may play an important role in the recruitment of lymphocytes, especially CTLs recruited to inflammation sites.