妊娠滋养细胞疾病相关因素病例对照研究

Case-control Study of The Relating Factors on Trophoblastic Disease

目的 探讨妊娠滋养细胞疾病发病率及其相关因素。 方法 采用回顾性研究的方法对 1 991年 1月～ 2 0 0 2年 1 2月 2 5 796妊娠妇女临床资料进行分析 ,根据妊娠转归不同对其中 85例妊娠滋养细胞疾病患者采用1∶ 2配对病例对照研究。 结果 妊娠滋养细胞疾病发病率按各年份分析为 (1 2 0～ 5 0 5 ) / 1 0万 ,平均 32 9/ 1 0万。妊娠滋养细胞疾病发生与妊娠年龄相关 ,<2 0岁和 >4 0岁发生率高 ,分别为 795 / 1 0万和 336 1 / 1 0万 ;居住地在农村者的危险度为城市的 3.1 2倍 (P<0 .0 1 ) ;妊娠妇女血型 A型者的危险度为非 A型者的 2 .6 8倍 (P<0 .0 5 ) ;初次妊娠的危险度为非初次妊娠的 1 .79倍 (P>0 .0 5 )。 结论 妊娠滋养细胞疾病发病率为 32 9/ 1 0万 ,发病与妊娠妇女年龄、居住地在农村、血型

Objective\ To study the incidence rate of trophoblastic disease and its relating factors.\ Methods\ The data of 25796 pregnant women treated between Jan 1991 and Dec 2002 in the first hospital affiliation of Fujian medical university were analyzed retrospectively.\ The data of 85 case of trophoblastic disease were study by 1∶2 matching case\|control study.\ Results\ The incidence rate of trophoblastic disease cases was between 120~505 per 100000 annually.\ The mean incidence rate was 329 per 100000.\ There was significant correlated between the incidence trophoblastic disease and the pregnancy age.\ The incidence rate of trophoblastic disease was higher under 20 and above 40 pregnancy age.\ The relative risk on countryside was 3.12 times than in city (P<0 01).\ In blood group A the relative risk was 2.68 times(P<0.05).\ In the first pregnancy the relative risk is 1.79 times.\ \{Conclusion\}\ The incidence rate of trophoblastic disease is 329 per 100000.\ There are many relating factors such as the age of pregnancy women, dwelling on countryside and the blood group A in trophoblastic disease.