摘要
CALPAIN-10(CAPN-10)是一个Ca^(2+)依赖性的半胱氨酸蛋白酶的家族,其基因编码672个氨基酸,有15个外显子,其全长为31 kb。最新研究发现,CAPN10的3种多态性及变异同时存在,可使糖尿病的危险性增加3倍,近年来世界各国学者在不同种群中就CAPN-10与Ⅱ型糖尿病的关系进行着研究,发现两者的关系有正相关也有负相关,且存在着种族差异性。
The CAPN10 gene, which encodes calpain-10 ( CAPN10 ), a nonlysosomal cysteine protease expressed in many tissues, including skeletal muscle, liver, and pancreas, was positionally cloned within the NIDDM1 region. This putative diabetes susceptibility gene encodes a 672 amino-acid protein. Horikawa et al, determined that the CAPN10 gene consists of 15 exons and spans 31 kb. Recently, researchers in many countries have examined the impact of CAPN-10 gene on T2DM. The three SNPs existence simultaneously can increase threefold risk of T2DM. The correlation between them with racial diversity is also reviewed.
出处
《中国药理学通报》
CAS
CSCD
北大核心
2003年第6期618-621,共4页
Chinese Pharmacological Bulletin
基金
国家自然科学基金
No 30160091
