不稳定心绞痛血浆oxLDL水平升高的临床意义

The clinical significance of oxLDL in unstable angina

目的 :探讨血浆氧化低密度脂蛋白 ( ox L DL)水平与不稳定心绞痛 ( U A)严重程度和预后的关系。方法 :用 EL ISA法检测 69例不稳定心绞痛 ( UA组 ,包括低危组 16例、中危组 3 0例、高危组 2 3例 )及 42例稳定型心绞痛( SA组 )血浆 ox L DL水平。根据住院期间有无心血管事件 ,U A分为 :难治组 17例和趋稳定组 5 2例。结果 :U A组血浆 ox L DL 水平明显高于 SA组 ( P<0 .0 1) ;UA难治组明显高于 U A趋稳定组 ( P<0 .0 1) ;血浆 ox L DL 水平与 U A危险度分层具有极好的正相关性 ( P<0 .0 1)。结论 :血浆 ox L DL 水平升高是 U A的一个危险因子 ;ox L DL 可作为 U

Objective:To study the relationship between plasma oxidized low density lipoprotein (oxLDL)and the severity and prognosis of unstable angina.Methods:We measured the plasma level of oxLDL by ELISA in 69 patients with ustable angina (including 16 patients in low risk,30 patients in middle risk,and 23 in hisk risk) and 42 patients with stable angina . According to the in-hospital outcome , 69 UA patients were divided into 2 subgroups : UA with cardic events and UA without cardic events. Results: Plasma oxLDL level was higher in UA patients than in SA patients(P<0.01) ; Plasma oxLDL level was significantly higher in UA patients with cardic events than without cardic events(P<0.01); A significant positive correlation between the Plasma oxLDL levels and 3 categories of Braunwald's classification(P<0.01). Conclusions: A high Plasma oxLDL level is a risk factor for severity and worse prognosis in UA patients.