第二信使系统和其介导的基因表达对针灸效应影响的研究

Advances of Studies on the Involvement of the Second Messenger System and Gene Expression in the Effect of Acupuncture

从微观水平研究针灸效应对揭示其机理有重要的意义。本文从第二信使系统和其介导的基因表达对针灸效应影响的研究方面综述了针灸效应的终结反映于细胞内生物效应的变化(即对机体不同器官组织细胞内的物质代谢调节 ) ,从一个侧面提示 。

In the present paper,the authors review recent progresses of researches on the mechanisms of acupuncture in regulating organism's functional activities via the second messenger system and gene expression.① Quite a few studies prove that the second messenger system including cAMP,cGMP,Ca 2+ ,myoinositol triphosphate (IP 3) and diglyceride (DG) is involved in the meridian phenomenon or the effect of acupuncture, for example, cAMP and cGMP in the brain participate in the analgesic effect of electroacupuncture, and the protective effect on ischemic cerebral cells via lowering calmodulin level. Ca 2+ level is higher in the tissues of acupoints and the meridian running trace. ② Acupuncture may evoke c fos expression of the paraventricular nucleus of the hypothalamus; up regulate the expression of heat shock protein of the cardiac myocytes in heart operation patients and cerebral ischemia rats; down regulate cerebral NOS and bax protein expression in cerebral ischemia rats; suppress the expression of IL 1β mRNA and IL 6 mRNA in the cerebral cortex, cerebellum and the pituitary of senile rats, etc.