生物医用脂肪族聚氨酯的合成、表征及血液相容性研究

Synthesis,Characterization and Blood Compatibility Studies of Biomedical Aliphatic Polyurethanes

采用一步法合成以 4 ,4 '-甲烷二环已基二异氰酸酯 (HMDI)、扩链剂 1,4 -丁二醇 (BDO)为硬段 ,聚四氢呋喃醚 (PTMG)为软段的脂肪族聚氨酯。并对所合成材料进行了傅立叶变换红外光谱分析、力学性能测试、水接触角测试、溶血实验及体外静态血小板粘附实验。结果表明 ,本论文合成的聚氨酯断裂强度可达 30 MPa以上 ,可与芳香族聚氨酯材料相比拟 ,而其断裂伸长率、断裂永久形变、亲水性能较之更好 ,具有理想的机械力学性能。溶血实验和体外静态血小板粘附实验显示该材料具有优良的血液相容性。该材料在生物医学领域 ,尤其是介入诊疗和医用薄膜产品方面有极大的应用潜力 。

The one-step method was adopted to synthesize aliphatic polyurethane with 4,4-methylene dicyclohexyl diisocyanate (HMDI), 1,4-butanediol (BDO) and poly (tetrahydrofuran) (PTMG). The tests conducted on this material were FIR spectrum, mechanical properties test, water contact angles test, hemolysis test and platelet adhesion test. The results show that this material has a good tensile strength up to 30 MPa, similar to aromaphatic polyurethane. But its tensile elongation, tensile permanent change and hydrophility are better than that of aromaphatic polyurethane. The hemolysis test and platelet adhesion test show that it has good blood compatibility.