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蛋白激酶C激活与糖尿病血管并发症研究的新进展 被引量：3

The development about activation of protein kinase C and diabetic vascular complications
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摘要 蛋白激酶C(PKC)是一类由多种同工酶组成的丝氨酸 /苏氨酸蛋白激酶家族。高血糖和游离脂肪酸 (FFA)可影响信号传导通路 ,特别是激活二酰甘油 (DG) PKC途径 ,PKC的激活可引起胰岛素抵抗 (IR)及糖尿病血管并发症。PKC β选择性抑制剂 (LY 3335 31) Protein kinase C(PKC) is a serine/threonine kinase groups including a series of isoenzyme.Hyperglycemia and elevated free fatty acid can affect signal transduction pathway function,in particular activation of diacylglycerol (DG) and PKC,which occurs in the diabetic state. Activation of PKC lead to insulin resistance and diabetic vascular complications. PKC β isoform selective inhibitor(LY 333531) and vitamin E have shown potential effect as therapies for diabetic vascular complication.
作者 李宏亮 余叶蓉
机构地区 四川大学华西医院内分泌科
出处 《医学研究生学报》 CAS 2003年第9期708-709,713,共3页 Journal of Medical Postgraduates
关键词 蛋白激酶C 胰岛素抵抗 糖尿病血管并发症 Protein kinase C Insulin resistance Diabetic vascular complication
分类号 R587.1 [医药卫生—内分泌]
  • 相关文献

参考文献18

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  • 2Ha H,Yu MR,Choi YJ et al.Activation of protein kinase C-delta and C-epsilon by oxidative stress in early diabetic rat kidney[J].Am J Kidney Dis,2001,384 (suppl):s204-207.
  • 3石海燕,付方明,董砚虎.蛋白激酶C激活与胰岛素抵抗及糖尿病血管并发症[J].国外医学（内分泌学分册）,2002,22(5):316-319. 被引量：5
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二级参考文献16

  • 1Lu X, Yang X Y, Howard R L, et al. Fatty acids modulate protein kinase C activation in porcine vascular smooth muscle cells independently of their effect on de novo diacylglycerol synthesis[J].Diabetologia,2000,43:1136-1144.
  • 2Ha H, Yu M R, Choi Y J, et al. Activation of protein kinase C-delta and C-epsilon by oxidative stress in early diabetic rat kidney[J].Am J Kidney Dis,2001,384 (Suppl):s204-s207.
  • 3Yu W, Niwa T, Fukasawa T, et al. Synergism of protein kinase A, protein kinase C, and myosin light-chain kinase in the secretory cascade of the pancreatic beta cell[J].Diabetes,2000,49:945-952.
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  • 5Ikeda Y, Olsen G S, Ziv E, et al. Cellular mechanism of nutritionally induced insulin resistance in Psammomys obesus:overexpression of protein kinase C epsilon in skeletal muscle precedes the onset of hyperinsulinemia and hyperglycemia[J].Diabetes,2001,50:584-592.
  • 6Motley E D, Kabir S M, Eguchi K, et al. Protein kinase C inhibits insulin-induced Akt activation in vascular smooth muscle cells[J].Cell Mol Biol,2001,47:1059-1062.
  • 7Bandyopadhyay G, Sajan M P, Kanoh Y, et al.Glucose activates protein kinase C-zeta/lambda through proline-rich tyrosine kinase-2,extracellular signal-regulated kinase and phospholipase D.A novel mechanism for activating glucose transporter translocation[J].J Biol Chem,2001,276:35537-35545.
  • 8Bandyopadhyay G, Standaert M, Galloway L,et al. Evidence for involvement of protein kinase C(PKC)-δ and noninvolvement of diacylglycerol-sensitive PKCs in insulin-stimulated glucose transport in L6 myotubes[J].Endocrinology,1999,138:4721-4731.
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  • 10Standl E, Schnell O. Endothelial function in health and disease:new insights into the genesis of cardiovascular disease[J].Am J Med,2000,105:32S-39S.

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医学研究生学报
2003年 第9期

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