HMG-CoA还原酶抑制剂对X综合征血管内皮功能的影响

THE EFFECT OF HMCRCOA REDUCTASE INHIBITOR ON ENDOTHELIUM FUNCTION IN X SYNDROME

目的 :通过应用HMG -CoA还原酶抑制剂 (普伐他汀 )对x综合浆内征患者的血管内皮功能的影响 ,观察微血管病变引起的心肌缺血的改善作用。方法 :严格筛选 17例临床表现为胸痛并已作冠脉造影正常的患者服用普伐他汀 10mg。每晚睡前服 1次 ,疗程 3个月 ,用药前后进行血浆内皮素 (ET)的检测及活动平板运动试验 ,比较用药前后各项指标的变化情况。结果 :血浆ET水平较治疗前明显降低 (P <0 .0 1) ,运动出现心绞痛ST段改变的时间明显延长 (P <0 .0 5 ) ;ST段恢复时间显著缩短 (P <0 .0 5 )运动后 4分时相各导联运动诱发的ST段缺血型下降之和 (∑ST)明显减少。结论 :HMG -CoA还原酶抑制剂 (普伐他汀 )可显著改善X综合征患者的血管内皮功能异常 ,减轻心肌缺血 。

Objective:To observe the improvement on micro-vessel disorder oriented ischemia by the effect of HMG-CoA reductase inhibitor on endothelium function in X syndrome.Methods:Seventeen patients with chest pain and no coronary lesion by CAG were treated with Pravastatin 10m8 qn, 3 months. Serum Endothelin (ET) examination and treadmill exercise test were evaluated before and after treatment.Results:Serum ET level is much lower after treatment (P<0.01).Occurrence of anginal ST segment change was postponed significantly during treadmill exercise test (P<0.05). Time needed for ST segment recovery was shortened significantly (P<0.05). Sum of ST segment depression in each lead induced after 4 minutes movement was decreased obviously.Conclusions: HMG-CoA reductase inhibitor (Pravastatin) could significantly improve the disorder of endothelium function in X syndrome and myocardial ischemia patients.It possesses treatment efficacy on X syndrome.