肝病患者血清糖类抗原CA199化学发光法检测的临床意义

THE CLINICAL VALUE OF DETECTING CARBOHYDRATE ANTIGEN 199 LEVEL IN THE HEPATISM PATIENTS BY MEANS OF CHEMILUMINESCENT IMMUNOASSAY

目的 :观察肝病患者 (包括肝癌 ,肝硬化及轻度乙肝患者 )血清糖类抗原CAl99含量变化并探讨化学发光法检测血清糖类抗原CAl99的临床价值。方法 :3 0例正常人和 60例肝病患者 (其中 2 0例肝癌 ,2 0例肝硬化和 2 0例轻度乙肝患者 )用化学发光法检测其血清糖类抗原CA199含量 ,将所得值进行t检验。结果 :正常人血清CA199值 3 .75± 2 .89U/ml,轻度乙肝组略升高CA199值 5 .79± 3 .5 7U/ml(P <0 .0 5 ) ;肝硬化组较正常升高 14.67± 8.98U/ml(P <0 .0 1) ;肝癌组升高明显 85 .18± 60 .79U/ml(P <0 .0 0 1)。结论

Objective:To observe the changes of carbohydrate antigen 199(CA199) level in serum of the hepatism patients (including hepatocarcinoma, hepatocirrhosis and minor hepatitis B patients)and to study the clinical valve of detecting CA199 by using chemiluminescent immunoassay (CLIA).Methods:30 normal persons, 60 hepatism patients(including 20 hepatocarcinoma patients; 20 hepatocirrhosis patients and 20 minor hepatitis B patients, respectivly)were detected the level of CA199 in serum by using CLIA and analysized the results by using t test.Results:The CA199 level in serum of the 30 normal persons was 3.75±2.89U/ml; the level of CA199 in the minor hepatitis B patients was higher than that in the normal it was 5.79±3.57U/mi(P<0.05); the hepatocirrhosis' was higher than that in the normal persons it was 14.67±8.98U/ml(P<0.01); the level of CA199 in the hepatocarcinoma patients was highest among all patients, it was 85.18±60.79U/mi(P<0.001). Conclusions:The CA199 detection by using CLIA is important value for diagnosing the hepatocarcinoma.