24h尿排钠量测定对指导高血压病患者低钠盐饮食治疗的作用

EFFECT OF TWENTY-FOUR HOURS URINARY NATRIUM EXCRETION ASSAY TO GUIDE PRIMARY HYPERTENSION PATIENTS' LOW SODIUM DIET THERAPY

目的 :高血压病患者在日常生活中行低钠盐饮食治疗时常难以准确定量 ,而尿排钠量 (UNE)与饮食钠摄入量密切相关 ,本文通过测定 2 4h尿UNE ,旨在定量地指导患者调节饮食。方法 :10 9例原发性高血压病患者行普通饮食 1# (NaCl 15 g/d) 1周 ,留 2 4h尿作UNE测定 ,并空腹抽血查血清钠 ;随后予以普通饮食 2 0(10g/d)和低钠盐饮食 (5 g/d)各 1周 ,重复上述检查。结果 :进食低钠盐饮食时患者UNE较其进普通饮食 1#和 2 # 时均减少 (P <0 .0 0 1) ,而血清钠浓度无明显变化。结论 :根据 2 4h尿UNE测定的结果 。

Objective:A method of twenty-four hours urinary natfium excretion (UNE) assay is developed for guiding primary hypertension patients' low sodium diet therapy. Methods:Having one week's general diet 1 # (NaCl, 15gm/d), one hundred and nine light-moderate primary hypertension patients began to keep 24 hours urine.Next day 24 hours UNE and serum natrium concentrations were measured. Then after having general diet 2 # (10g/d) and low sodium diet (5g/d) each week, above-mentioned examinations were repeated.Results:Having low sodium diet, 24 hours UNE is decreased significantly compared with having general diet 1 # and 2 # (P<0.001).Conclusions: According to the result of 24 hours UNE, we can guide essential hypertension patients' low sodium diet therapy properly.