左旋精氨酸对肝缺血-再灌注损伤时血小板聚集功能的影响

Effects of L-arginine on the function of platelet aggregation during hepatic ischemia/reperfusion injury

目的 探讨左旋精氨酸 (L Arg)对肝缺血再灌注损伤 (HIRI)时血小板聚集功能的影响。方法 选择 HIRI实验兔及肝癌手术患者 ,观察血小板最大聚集率 (Ptmax)、最大聚集时间 (Pt T)及聚集坡斜率(Pt S)的变化及 L Arg的调控作用。结果 实验动物和肝癌手术患者肝缺血再灌注期间 ,Ptmax和 Pt S均明显增加 (P<0 .0 5和 P<0 .0 1) ,Pt T均显著缩短 (P均 <0 .0 5 ) ;使用 L Arg后 ,上述指标的异常变化均显著减轻 ,其差异均有显著性意义 (P<0 .0 5和 P<0 .0 1)。结论 L Arg对 HIRI时血小板聚集功能有明显的调控作用。

Objective To explore the effects of L-arginine (L-Arg) on the function of platelet aggregation during hepatic ischemia-reperfusion injury(HIRI). Methods The changes in maximum aggregating rate of circulating platelets(Pt max), its maximum aggregating time(PtT) as well as its aggregating slopes(PtS) were measured. Effects of L-Arg on those parameters were observed during HIRI in 20 rabbits and 18 patients who were scheduled for elective hepatic surgery. Results Pt max and PtS all increased significantlly (P<0.05 and P<0.01), while PtT decreased remarkably(both P<0.05) during HIRI of rabbits and patients. After treatment with L-Arg, the abnormal changes of parameters as above were all alleviated remarkably (P<0.05 and P<0.01). Conclusion It is indicated that L-Arg can effectively regutate the function of platelet aggregation during HIRI.