布洛芬不良反应危险因素分析和判别(英文)

Risk factor analysis and discrimination of adverse drug reactions to ibuprofen

目的 :观察分析布洛芬的不良反应和相关的危险因素。方法 :采用分层整群抽样 ,回顾性访问的方法调查了上海市 9家医院的风湿科门诊病人 ,采用R×C χ2 或Wilcoxon秩和检验进行单因素分析 ;采用logistic逐步回归进行多因素分析 ,分析引起布洛芬不良反应的相关因素 ,并建立判别方程。结果 :共 447位病人入选本次调查 ,其中有 1 4 4例(32 .2 % )发生不良反应。经过分析判别 ,单因素分析结果显示“合并用药史”、“疾病家族史”、“服用可乐的时间”、“与服药以前半年的健康状况比较”、“过去 4wk内感到心情抑郁的程度”、“在服药NSAIDs前 4wk内感到筋疲力尽的程度”、“觉得无助从而影响生活质量”、“觉得无法自控从而影响生活质量”、“觉得仇视从而影响生活质量”与不良反应的发生有关。进一步用logistic逐步回归分析显示 8个因子“合并用药史”、“吸烟史”、“能接受一些无法改变的事情”、“对服药前自身健康的总体评价”、“可乐的服药时间”、“与服药以前半年的健康状况比较”、“健康状况对活动影响 (第 1主成分 )”、“个人财务对生活的影响”与不良反应的发生相关。同时得出了引起布洛芬不良反应的相关因素以及判别方程并进行了敏感度和特异度分析。结论

AIM: To observe adverse drug reactions(ADRs) caused b y ibuprofen and analyze related risk factors. METHODS: By using stratified clu ster sampling, a retrospective survey was conducted on outpatients from the rheumatic departmen ts of 9 hospitals in Shanghai. Analytical methods including univariate analysis and logistic stepwise regression were adopted to identify risk factors for ADRs induced by ibuprofen and to establish a discriminatory equation. RESULTS: Four hundred and forty-seven patients were enrolled in the survey, 144 (32.2 %) of which had ADRs to ibuprofen. Risk factors were identified and a discriminatory equation was established based on the statistical results. CO NCLUSION: The occurrence of ibuprofen ADRs is affected by multiple factors. The sensitivity and specificity of logistic stepwise regression analysis discriminat ory equation are low. This indicates that maybe only part of the risk factors h ave been discovered in the study.