摘要
目的 :观察多塞平治疗肠易激综合征 (IBS)的临床疗效 ,进一步探讨IBS的病因和治疗原则。方法 :1 0 3例IBS病人 ,其中多塞平组 71例 [男性 32例 ,女性 39例 ,年龄 (46±s 1 3)a] ,给予多塞平 2 5mg ,po,qn;胰酶组 32例 [男性 1 8例 ,女性 1 4例 ,年龄 (48± 1 1 )a ] ,给予胰酶 1 50mg,po,tid;均以 8wk为一个疗程。利用症状等级评分表和SF 36健康调查量表对治疗前后的肠道症状和生活质量进行评估 ,观察疗效。结果 :多塞平组和胰酶组的总有效率分别为 86 % (61 / 71 )和 44 % (1 4 / 32 ) ,两组相比差异有非常显著意义 (P <0 .0 1 ) ,多塞平组各亚型之间疗效比较差异无显著意义 (P >0 .0 5)。多塞平治疗后病人的生活质量有所提高 ,以总体健康、活力和精神健康纬度积分为明显。结论 :多塞平对IBS病人肠道症状也有较好的治疗作用 ,且能改善病人的生活质量。
AIM: To observe the efficacy and safety of doxepin in the treatment of irritable bowe l syndrome(IBS) and explore further the cause of IBS and its therapy principle. METHODS: One hundred and three patients with IBS were divided into two groups. Doxepin group of 71 patients(M 32, F 39; age(46±s 13)a) was treated with doxepin 25 mg, qn,for 8 wk. Pancreatin group of 32 patients (M 18, F 14;age(48±11)a) was treated with pancreatin capsule 450 mg, tid, for 8 wk. Syndrome scales and SF-36 Health Survey Scales were used to evaluate the ef f icacy in gastrointestinal syndrome and quality of life before and after treatme nt. RESULTS: For treatment of irritable bowel syndrome, there was significant d ifference between the effect ive rate of doxepin group and that of pancreatin group, which was 86 % and 44 %, respectively. No sign ificant differences were observed among each subtypes in doxepin group. Quality of the patients' life was obviously improved in the general health (GH), vitali ty (VT) and mental health(MH) after treatment in doxepin group. CONCLUSION: Dox epin is effective in the treatment of IBS and it can improve th e quality of life.
出处
《中国新药与临床杂志》
CAS
CSCD
北大核心
2004年第2期79-82,共4页
Chinese Journal of New Drugs and Clinical Remedies
关键词
多塞平
结肠疾病
功能性
抗抑郁药
药物疗法
doxepin
colonic diseases,functional
antidepressive agents
drug therapy