股动脉药物注射治疗下肢血管血栓性疾病临床观察

Clinical observation on medicament administration through lower limb vessel to treating thrombotic disease

目的 :观察股动脉注射小剂量尿激酶 ,降纤酶对下肢血管血栓的临床疗效。方法 :225例患者经血管彩色多普勒超声检查证实下肢血管血栓形成 ,用小剂量尿激酶与降纤酶交替于患侧股动脉内注射后 ,观察患者治疗前后血流变学 ,纤维蛋白原 ,血小板计数等及血管彩色多普勒超声检查血管血栓处有效腔和血栓大小的变化。结果 :股动脉注射小剂量尿激酶 ,降纤酶 ,治疗下肢血管血栓有效 ,且病程越短疗效越好。结论 :股动脉注射小剂量尿激酶 ,降纤酶治疗下肢血管血栓是安全有效的 ,同时也简便易行 。

Objective:To observe the effect of low-dose urokinase defibrase on the patients with lower limb vessel thrombi and its mechanism.Methods:225patients who were demonˉstraded to have lower limb vessel thrombosis by color Doppler ultrasound were treated with low dose urokinase defibrase through a intra-femoral arterial infusion to the affected lower limbs.The clinical curative effects,blood rheology,fibrinogen were observed.Results:The low dose urokinase defibrase given with intra-femoral arterial infusion was effective on onset of symptom.Conclusion:Low-dose urokinase defibrase of intra-femoral infusion is an effective and safe for treating lower limb vessel thrombi.