二氧化碳吸收剂中水分对七氟醚分解反应的影响

Effect of water content of carbon dioxide absorbents on the products from sevoflurane breakdown in a closed-chamber

目的 研究模拟紧闭反应器内干燥的二氧化碳 (CO2 )吸收剂及自身含水对七氟醚分解的影响。方法 在紧闭反应器 (1 6 0ml)内 ,分别装钠石灰、钡石灰、干燥钠石灰和干燥钡石灰 (各 2 5g)。在密闭状态下注入液态的七氟醚 4 0 0 μl,放入 5 0℃水浴内反应 6h ,分别在 5、1 5、30、4 5、6 0min、以后每 30分钟至 36 0分钟采样 ,用气相色谱法分析。测定七氟醚的分解产物。结果 钠石灰组出现复合物A、B ,在其他组七氟醚产生 5种分解产物。复合物A∶干燥钡石灰 >干燥钠石灰 >钡石灰和钠石灰组。干燥钡石灰组明显高于其他两组 (P <0 0 5 )。复合物B∶干燥钡石灰组 <钡石灰组 <干燥钠石灰组 (P <0 0 5 )。复合物C、D、E ,以干燥钡石灰组最为明显 (P <0 0 5 )。各组均未检测到CO。结论 在 5 0℃的紧闭反应器内 ,七氟醚与干燥的CO2 吸收剂反应剧烈 ,未产生CO ;国产钠石灰优于钡石灰 。

Objective To investigate the effects of water content of sodalime (Gangyu,China)and baralyme on the breakdown products of sevoflurane in a closed reaction chamber at 50 ℃.Methods dried baralyme,dried sodalime,baralyme and sodalime were placed in the closed chamber(160 ml),which were placed separately into the water bath at 50 ℃.Sevoflurane(400 μl)was dropped in the closed chamber.400 μl sampling gas was taken for the measurements at 5,15,30,45,60 min and every 30 min until 360 min thenafter.Two gaschromatographies were equipped for detection of breakdown products of sevoflurane.Results No carbon monoxide was detected in the four groups.Compound A and B were detected in sodalime group.Sevoflurane was breakdown rapidly,and compound A was appeared in the four groups.The intense of the reaction was in an order of dried baralyme>dried sodalime >baralyme>sodalime.Compound A was found in an order of dried baralyme >dried sodalime>baralyme>sodalime,and Compound B was dried baralyme<baralyme<dried sodalime. Compound C,D,E were also appeared in dried baralyme,baralyme and died sodalime.Conclusion Sevoflurane breakdown happens vigorously in dried carbon dioxide absorbents in the closed reaction chamber at 50 ℃.Water from sodalime or baralyme can reduce the breakdown of sevoflurane in the closed chamber at 50 ℃.Sodalime shows smaller products than baralyme.