不同年龄健康者不同部位骨密度分析

Analysis of bone mineral density at different parts in healthy volunteers of different ages

目的:分析不同年龄健康志愿者腰椎及髋部不同部位骨密度结果,提高早期诊断骨质疏松的依据。方法:对300名健康志愿者,年龄30～79岁,男110名,女190名,应用双能X线骨密度吸收仪测定腰椎及髋部不同部位(股骨颈、Ward’s三角、大转子)骨密度,并按不同年龄组进行结果分析。结果:①女性腰椎2～4(L2-4)BMD50岁后下降明显(t=3.96～5.62,P<0.001);股骨颈和Ward’s三角BMD随年龄增加而下降(各组间差异t=2.01～6.91,P<0.05～0.001,t=2.88～7.34,P<0.001);大转子BMD在50岁组和60岁组与其他各年龄组之间有明显的下降(t=4.19～5.24,P<0.01～0.001)。②110名男性L2-4BMD各组间比较无明显差异;股骨3个部位的BMD50岁后随年龄增加而下降(各组间差异t=2.13～0.87,P<0.05～0.001)。③女性BMD4项值与年龄及绝经年限明显负相关(r=-0.312,P<0.01;r=-0.532,P<0.01;r=-0.418,P<0.01;r=-0.642,P<0.001);男性与年龄及BMI的相关性不明显。结论:女性在更年期后以L2-4BMD下降为主;男性以髋部BMD变化为主。骨密度的测定提供了早期诊断骨质疏松的依据。

AIM:To explore the bone mineral density(BMD) at different parts in healthy vo lunteers of different ages, and provide evidence for early diagnosis of osteopor osis. METHODS:A total of 300 healthy volunteers(110 males and 190 females),aged 30-79 years old,were measured the BMD at the different parts of the lumbar spine and hip( neck of femur,Ward's triangle,greater trochanter) by dual energy X- ray absorptiometry(DEXA)(Norland Excell plus),the results were analyzed accordi ng to different age groups. RESULTS:① The BMD of lumbar spine 2-4(L2-4) in females decreased signifi cantly after 50 years old( t=3.96-5.62,P< 0.001) , the BMD of neck of femur and Ward's triangle decreased with the increase of age( t=2.01-6.91, P< 0.05-0.001, t=2.88-7.34, P< 0.001) ;the BMD of greater trochanter in the 50 an d 60 years old group was significantly lower than other groups(t=4.19-5.24, P< 0.01-0.001).② BMD of L2-4 was not significantly different in each male gro up.BMD at 3 different parts of femur decreased with the increase of age after 50 years old (t=2.13-0.87,P< 0.05-0.001).③ The 4 values of BMD in females wer e of negative correlation significantly with age and time limit of menopause(r=-0.312, P< 0.01,r =-0.532,P< 0.01, r =-0.418,P< 0.01,r =-0.642, P< 0.00 1),while those in males were no correlated with age and body mass index. CONCLUSION:The decrease of L2-4 BMD is the main trend of females after meno pause, while that of males is the changes of BMD of hip.The measurement of BMD p rovides evidence for early diagnosis of osteoporosis, and is good for the early prevention and cure of osteoporosis.