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原子力显微镜在生物力测量中的应用 被引量:6

Direct measurement of force in biology with AFM
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摘要 利用原子力显微镜 (AFM )能够实现生物分子间作用力直接测量。本文讨论了利用AFM测量配体 受体之间的相互作用力、细胞粘着力、核酸双链和碱基对氢键间的作用力、运动蛋白之间的作用力。 With direct measurement force of small biological structures by AFM, the interactions have been measured hitherto include: ligand receptor, protogltycans, DNA complementary strands and nucleorides, actin myosin, special organic chemical group.
出处 《微纳电子技术》 CAS 2003年第7期228-230,共3页 Micronanoelectronic Technology
基金 留学回国人员科研启动基金资助项目
关键词 原子力显微镜 生物力测量 AFM 细胞粘着力 核酸双链 interaction measuring method AFM force quanta
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  • 1[1]CREIGHTON T. Proteins: Structures and Molecular Properties [M]. New York: W.H. Freeman, 1993.
  • 2[2]HEINZ W F, HOH J H. Spatially resolved force spectroscopy of biological surfaces using the atomic force microscope [J]. Trends Biotechnol., 1999, 17: 143-150.
  • 3[3]ASHKIN A, DZIEDZIC J M, YAMANE T. Optical trapping and manipulation of single cells using infrared laser beams [J]. Nature, 1987, 330: 769-771.
  • 4[4]ENGEL A, LYUBCHENKO Y, MUELLER D. Atomic force microscopy: a powerful tool to observe biomolecules at work [J]. Trends Cell Biol, 1999, 9: 77-80.
  • 5[5]FLORIN E L, MOY V T, GAUB H E.Adhesion forces between individual ligand-receptor pairs[J].Science, 1994, 264: 415.
  • 6[6]WONG J, CHILKOTI A, MOY V T. Direct force measurements of the streptavidin-biotin interaction [J]. Biomolecular Engineering, 1999: 1645-1655.
  • 7[7]DAMMER U, POPESCU O, WAGNER P, et al. Binding strength between cell adhesion protogltycans measured by atomic force microscopy [J]. Science, 1995, 267: 1173.
  • 8[8]LEE G U, CHRISEY L A, COLTON R J. Direct measurement of the force between complementary strands of DNA [J]. Science, l994, 266: 771-772.
  • 9[9]BOLAND T, RATNER B D. Direct measurement of hydrogen binding in DNA nucleotide base by atomic force microscopy[J].Proc Natl Acad Sci, l995, 92(12): 5297.
  • 10[10]ISHIJIMA A, DOI T, SAKURADA K. Sub-piconewton force fluctuations of actomyosin in vitro [J]. Nature, l991, 352: 301.

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