期刊文献+
任意字段
题名或关键词
题名
关键词
文摘
作者
第一作者
机构
刊名
分类号
参考文献
作者简介
基金资助
栏目信息

GluR1在大鼠海马结构的表达 被引量：1

Expression of GluR1 in the hippocampus of rats
下载PDF
导出
摘要 目的 :观察AMPA受体亚单位GluR1在大鼠海马的表达 .方法 :在多聚甲醛固定的海马切片上 ,用免疫组化SP法观察GluR1在正常成年大鼠海马结构的表达与分布 .结果 :GluR1在正常大鼠海马有广泛表达 ,在CA3区的起层、锥体细胞层和透明层及齿状回门区内的中间神经元表达最强 .阳性表达在CA1区主要见于神经元的胞膜和突起 ,而在CA3区还可见于胞质 .结论 :GluR1在海马CA1区和CA3区的表达不同 ,这种差异可能与海马不同区域具有不同功能有关 . AIM: To investigate the expression of AMPA receptor subunit GluR1 in the hippocampus of rats. METHODS: The expression and distribution of GluR1 in hippocampus of rats were examined by using SP immunohistochemical staining method. RESULTS: There was a widespread expression of GluR1 in the hippocampus of adult rats, especially in stratum pyramidal cell, stratum orient and stratum lucidum of CA3 region, and interneuron of dentate gyrus. Positive expression was mainly located in the cytomembrane and processes of the neurons in the CA1 area, and also in the cytoplasm in the CA3 area. CONCLUSION: The expression of GluR1 in the hippocampal CA1 and CA3 area is different. This difference may be attributed to the different functions in different hippocampal subregions.
作者 蒋马莉 韩太真 杨东伟
机构地区 西安交通大学医学院生理学教研室
出处 《第四军医大学学报》 CAS 北大核心 2003年第20期1849-1850,共2页 Journal of the Fourth Military Medical University
基金 国家自然科学基金 (30 2 0 0 0 75) 西安交通大学重点培植项目 (1 60 0 82 0 0 3)
关键词 受体 AMPA GLUR1 海马 免疫组织化学 receptors, AMPA GluR1 hippocampus immunohistochemistry
分类号 R338 [医药卫生—人体生理学]
  • 相关文献

参考文献8

  • 1[1]Song I, Huganir RL. Regulation of AMPA receptors during synaptic plasticity [review] [J]. Trends Neurosci, 2002; 25(11):578-588.
  • 2[2]Lee HK, Takamiya K, Han JS, Man H, Kim CH, Rumbaugh G, Yu S, Ding L, He C, Petralia RS, Wenthold RJ, Gallagher M, Huganir RL. Phosphorylation of the AMPA receptor GluR1 subunit is required for synaptic plasticity and retention of spatial memory [J]. Cell, 2003; 112(5): 631-643.
  • 3[3]Reisel D, Bannerman DM, Schmitt WB, Deacon RM, Flint J, Borchardt T, Seeburg PH, Rawlins JN. Spatial memory dissociations in mice lacking GluR1 [J]. Nat Neurosci, 2002; 5(9):868-873.
  • 4[4]Shi SH, Hayashi Y, Esteban JA, Malinow R. Subunit-specific rules governing AMPA receptor trafficking to synapses in hippocampal pyramidal neurons [J]. Cell, 2001;105(3):331-343.
  • 5[5]Nusser Z. AMPA and NMDA receptors: Similarities and differences in their synaptic distribution [review] [J]. Curr Opin Neurobiol, 2000; 10:337-341.
  • 6[6]Barry MF, Ziff EB. Receptor trafficking and the plasticity of excitatory synapses [review] [J]. Currt Opin Neurobiol, 2002; 12:279-286.
  • 7[7]Kanterewicz BI, Urban NN, McMahon DB, Norman ED, Giffen LJ, Favata MF, Scherle PA, Trzskos JM, Barrionuevo G, Klann E. The extracellular signal-regulated kinase cascade is required for NMDA receptor-independent LTP in area CA1 but not area CA3 of the hippocampus [J]. J Neurosci, 2000; 20(9):3057-3066.
  • 8[8]Arai A, Lynch G. Response to repetitive stimulation of AMPA receptors in patches excised from fields CA1 and CA3 of the hippocampus [J]. Brain Res, 1996; 716:202-206.

同被引文献7

  • 1Bayer KU, Koninck PD, Leonard AS, et al. Interaction with the NMDA receptor locks CaMKII in an active conformation [ J ]. Nature, 2001 ;411: 801 -805.
  • 2Sheng M, Kim MJ. Postsynaptic signaling and plasticity mechanisms[ J ], Science, 2002 ;298: 776 - 780.
  • 3Liu LD, Wong TP, Pozza MF, et al. Role of NMDA receptor subtypes in governing the direction of hippocampal synaptic plasticity[J]. Science, 2004;304:1021 - 1024.
  • 4Castellani GC, Qinlan EM, Cooper LN, et al. A biophysical model of bidirectional synaptic plasticity: Dependence on AMPA and NMDA receptors [J]. PNAS, 2001 ;98: 12772 - 12777.
  • 5Shouval HZ, Bear MF, Cooper LN. A unified model of NMDA receptor-dependent bidirectional synaptic plasticity [ J ]. PNAS,2002 ;99 ( 16 ): 10831 - 10836.
  • 6Zhabotinskyd AM. Bistability in the Ca2 +/Calmodulin-dependent protein kinase-phosphatase system [ J ]. Biophys J, 2000; 79 ( 5 ):2211 - 2221.
  • 7Mulkey RM, Endo S, Shenolikar S, et al. Involvement of a calcineurin/inhibitor-1 phosphatase cascade in hippocampal long-term depression [J]. Nature, 1994 ;369:486 -488.

引证文献1

第四军医大学学报
2003年 第20期

相关作者

内容加载中请稍等...

相关机构

内容加载中请稍等...

相关主题

内容加载中请稍等...

浏览历史

内容加载中请稍等...
;
使用帮助 返回顶部