毒鼠强中毒治疗方法的对比分析

The Contrastive Analysis of Different Treatments of Acute Tetramine Intoxication

目的 分析不同治疗方案在治疗毒鼠强中毒 (ATI)中的作用 ,探索最佳的治疗方法。方法 回顾性统计近十年间我院67例ATI患者的治疗及住院情况 ,按治疗方法不同分为ABC三组 ,对比分析其死亡率及并发症等情况。结果 三种治疗方法中 ,C法死亡率最低 ( 13 .3 3 % ) ,B方法 ( 5 5 .5 6% )死亡率高于C法但低于A法 ( 2 8.0 0 % ) ,三者间有明显差异。结论 综合早期洗胃排毒、有效抗惊厥、抗毒鼠强毒性作用、应用特异性解毒药物 ,尤其是二巯基丙磺酸钠的使用 ,可明显降低死亡率、减少并发症。

Objectives To analyse the clinical effects of three treatment regimens of acute tetramine intoxication (ATI) and to search for the best one. Methods 67 cases of ATE in the past 10 years were divided into three groups different treatment. The treatment of group A is routine treatment. Sodium valproate was used in group B in addition to routine treatment. Unithiol was used in group C, the other treatment was same to group B. The mortality rate and complication were compared in each group. Results The difference of the mortality rate among three groups was significant. The mortality rate of C was lowest (13.33%), the mortality rate of group A was the highest (55.56%). Conclusions Earlier gastric lavage, effective anticonvulsion and using of specific antidote earlier, could reduce mortality rate and lessen complication.