模拟深埋人员缺氧复合缺水缺食时血气参数变化研究

Study on the changes of blood-gas parameters under condition of hypoxia combined with deprivation of food and water of simulated deeply buried

目的:研究模拟深埋条件下缺氧复合缺水缺食时动脉血气参数的变化规律和特点。方法:应用Wistar大鼠80只(雌雄各半)和雄性比格犬6只,前者随机分为单纯缺氧组(氧含量10%)、缺食缺水组、缺氧缺食缺水组和正常对照组,后者仅为缺氧缺水缺食,于致伤后第1天、第3天、第7天、第9天、第11天、第12天、第14天动态和对比性检测动脉血气和多种离子的浓度。结果:1.缺氧缺食缺水组比格犬于11.9～14.9天全部死亡,其PaO_2和PaCO_2值于第1天即均显著下降(P<0.01),持续至死亡,分别仅为伤前的48.5%～55.5%和56.5%～66.4%,红细胞比容(Hct)比值同样于第1天即显著增高,最高达到75.0%;Na^+和Cl^-浓度分别在第5天和第1天后即明显增高,K^+度仅略呈升高趋势;2.大鼠动脉血气和多种离子的浓度变化与比格犬组基本呈类似规律,其中动脉血气变化于雄性和雌性组间差异不显著,而血Na^+、Cl^-和K^+浓度则以雄性较雌性显著。结论:深埋条件下缺氧复合缺水缺食时发生动脉血PaO_2和PaCO_2值下降,血清离子浓度紊乱和血液浓缩,具有快速性、持续性和进行性特点。

Objective:To study the development and characteristics of artery blood-gas parameters under condition of hypoxia combined with deprivation of food and water of simulated deeply buried. Methods:80 Wistar rats(half male and female)were randomly divided into control group,single hypoxia group(oxygen content 10%),deprivation of water and food group,and hypoxia combined with deprivation of water and food group. 6 male Beagles were randomly divided into control group and hypoxia combined with deprivation of water and food group. Artery blood-gas and many kinds of ionic contents were measured at 1 day,3 day,7 day,9 day,11 day,12 day and 14 day after injury. Results:1. The Beagles of three lack group all died during 11. 9～14. 9 days. The values of both PaO_2 and PaCO_2 decreased significantly at 1 day(P<0.01),and the percentages compared with before injury were only 48.5%～55.5% and 56.5%～66.4% respectively until death. Hct ratio was also increased obviously up to 75% at 1 day. Na^+ and Cl^- concentrations increased obviously at 5 day and 1 day respectively. K^+ concentration just showed a little increase trend. 2. Changes of the artery blood-gas and many kinds of ionic contents of rats were similar with Beagles. There were no significant difference seen in artery blood-gas between male and female rats. But the changes of Na^+,Cl^- and K^+ were more obvious in male rats than female rats.Conclusion:Under condition of hypoxia combined with deprivation of food and water of simulated deeply buried,the levels of artery PaO_2 and PaCO_2 decreased,disorder of serum ionic and blood concentration occurred and the character was rapid,continuous and progressive.