膦甲酸钠与喷昔洛韦治疗带状疱疹的疗效比较

Comparison of the efficacy of Foscarnet Sodium and Penciclovir in Treatment of Herpes Zoster

目的比较膦甲酸钠与喷昔洛韦治疗带状疱疹的疗效。方法选择在四个中心就诊符合诊断标准的带状疱疹患者为研究对象,采用随机、平行对照的临床试验。治疗组患者采用膦甲酸钠氯化钠注射液3.0 g,1次/12 h,静脉滴注,连用7 d。对照组患者采用注射用喷昔洛韦0.25 g,1次/12 h,静脉滴注,连用7 d。用药后第3、7、14天观察疗效。结果共入组226例,治疗后第3、7、14天,治疗组的有效率分别为19.30%、67.54%和93.86%,对照组分别为18.75%、65.18%和91.07%,两组有效率比较差异无统计学意义(P>0.05);治疗组止疱时间、水疱完全结痂时间、结痂全部脱落时间均短于对照组,但差异无统计学意义(P均>0.05);疼痛改变(NRS法分值)比较两组间差异无统计学意义(P>0.05)。治疗组有10例、对照组有11例出现PHN,差异无统计学意义(P>0.05)。结论膦甲酸钠与喷昔洛韦治疗带状疱疹的疗效相当。

Objective To compare the efficacy of foscarnet sodium and penciclovir in treatment of herpes zoster. Methods Patients diagnosed with herpes zoster in four clinical centers were selected as the research object in a randomized and parallel controlled clinical trial. The treatment group was treated with foscarnet sodium injection(3.0 g), every 12 hours for consecutive 7 days through intravenous drip. The control group was treated with penciclovir for injection with the same method and same dosage. The thrapeutic effects were observed and evaluated on the 3 rd,7 th and the 14 th day of medication. Results Altogether 226 cases were enrolled. The effective rates of the treatment group were 19.30%,67.54% and 93.86%,while the effective rates of the control group were 18.75%,65.18% and 91.07% after treatment at the 3 rd,7 th and the 14 th day,respectively,without significant differences between the two groups(P>0.05). There were also no significant differences between the two groups in the aspects of time to total resolution of vesicles,time to full crusting,time to full loss of crusts(P>0.05). There was no significant statistical difference between the two groups in the comparison of numerical rationg scales(NRS). Ten cases of postherpetic neuralgia occurred in treatment group,and 11 cases in control group,without significant difference between them(P>0.05). Conclusion Foscarnet sodium was as efficacious as penciclovir in the treatment of herpes zoster.