摘要
本研究采用Goldblatt氏高血压动物模型方法,对六只犬的右肾动脉施行了不完全性狭窄并应用放射免疫测定法,测定了实验动物手术前后血浆血管紧张素Ⅱ的变化。研究结果表明,术后犬血浆中血管紧张素Ⅱ增加并伴有动脉血压升高。因此,血管紧张素Ⅱ可被认为是肾性高血压发生的始动因素。由于左肾的代偿作用所有动物均无血浆钠、钾和血容量改变。
Renal hypertension was induced in G dogs by incomplete ligation of the right renal artery following Goldblatt's method. Plasma angiotensin Ⅱ was measured with radioimmunoassay before and after the operation. The results showed that the angiotensin Ⅱ in the plasma increased with the elevation of the arterial blood pressure, hence it was considered as an initiating factor in the occurrence of renal hypertension. Because of the compensatory effect of the left kidney, the sodium and potassium in the plasma and the blood volume remained unchanged.
出处
《中国病理生理杂志》
CAS
1985年第4期33-36,共4页
Chinese Journal of Pathophysiology
关键词
肾性高血压
血浆血管紧张素Ⅱ
钠
钾
血容量
放射免疫测定
Renal hypertension
Plasma angiotensin Ⅱ
Sodium
Potassium
Blood volume
Radioimmunoassay.