Mechanisms of axon regeneration

ailure of regeneration in injured axons accounts for permanent functional deficits after CNS injury.Thus,there has been a tremendous need to understand the mechanisms underlying regeneration failure.Previously,a predominant hypothesis held that extrinsic inhibitory factors in the adult CNS environment prevent injured axons from re-growth.However,blocking these inhibitory activities genetically led to little or no axon regeneration in vivo,suggesting that removing inhibitory activities alone is