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MicroRNA regulation of endothelial progenitor cell angiogenesis in diabetes 被引量：1

MicroRNA regulation of endothelial progenitor cell angiogenesis in diabetes
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摘要 Endothelial progenitor cells(EPCs)are a circulating,bone marrow-derived cell population that participate in both vasculogenesis and vascular homeostasis.Recent studies have shown that EPCs are reduced by^50% in diabetes that correlates inversely with its mortality rate.In addition,EPC angiogenic functions are severely impaired in diabetes.However,the molecular and cellular mechanisms underlying EPC dysfunction are poorly understood.Our current studies have focused on in vitro and in
作者 Alex F.Chen
机构地区 VA Vascular Surgery Research
出处 《中国病理生理杂志》 CAS CSCD 北大核心 2010年第A10期1946-1946,共1页 Chinese Journal of Pathophysiology
基金 Supported by Grants from NIH R01GM077352,VA Merit Award I01RX000244,AHA GIA0855601G,ADA Research Award7-08-RA-23 NSFC Overseas Collaborative Grant#30728021
关键词 PROGENITOR IMPAIRED HOMEOSTASIS EPCS understood ANGIOGENESIS poorly CIRCULATING underlying participate
分类号 R587.1 [医药卫生—内分泌]
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  • 1Tay Y, Zhang J, Thomson AM, et al. MicroRNAs to Nanog, Oct4 and Sox2 coding regions modulate embryonic stem cell differentiation [ J ]. Nature, 2008, 455 (7216) : 1124-1128.
  • 2Khraiwesh B, Arif MA, Seumel GI, et al. Transcriptional control of gene expression by microRNAs [ J ]. Cell, 2010, 140(1) : 111-122.
  • 3Reddy MA, Jin W, Villeneuve L, et al. Pro-inflammatory role of microRNA-200 in vascular smooth muscle cells from diabetic mice [ J ]. Arterioscler Thromb Vasc Biol, 2012, 32(3) : 721-729.
  • 4Villeneuve LM, Kato M, Reddy MA, et al. Enhanced levels of microRNA-125b in vascular smooth muscle cells of diabetic db/db mice lead to increased inflammatory gene expression by targeting the histone methyltransferase Suv39hl[J]. Diabetes, 2010, 59(11): 2904-2915.
  • 5Asgeirsdottir SA, van Solingen C, Kumiati NF, et al. Mi- croRNA-126 contributes to renal microvascular heterogene- ity of VCAM-1 protein expression in acute inflammation [J]. Am J Physiol Renal Physiol, 2012, 302 (12): F1630-F1639.
  • 6Zeng Z, Gong H, Li Y, et al. Upregulation of miR-146a contributes to the suppression of inflammatory responses in LPS-induced acute lung injury[ J]. Exp Lung Res, 2013, 39 ( 7 ) : 275-282.
  • 7Gonsalves C, Kalra VK. Endothelin-l-indueed macro- phage inflammatory protein-1β expression in monocytic cells involves hypoxia-inducible factor-1 ct and AP-1 and isnegatively regulated by microRNA-195 [ J]. J Immunol, 2010, 185(10) : 6253-6264.
  • 8Curtale G, Mirolo M, Renzi TA, et al. Negative regula- . tion of Toll-like receptor 4 signaling by IL-10-dependent microRNA-146b[J]. Proc Natl Acad Sci U S A, 2013, 110(28) : 11499-11504.
  • 9Staton AA, Knaut H, Giraldez AJ. miRNA regulation of Sdfl chemokine signaling provides genetic robustness to germ cell migration[J]. Nat Genet, 2011, 43(3) : 204- 211.
  • 10Liu KK, Dorovini-Zis K. Regulation of CXCL12 and CX- CR4 expression by human brain endothelial cells and their role in CD4 and CD8 T cell adhesion and transendothe- lial migration [ J ]. J N 49-64. 1, 2009, 215 (1-2).

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中国病理生理杂志
2010年 第A10期

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