Hemin restores the impaired endothelium-dependent vasodilatation in diabetic db/db mice and the possible mechanisms involved

Heme oxygenase(HO)is the enzyme that catalyzes the degradation of heme and leads to the formation of carbon monoxide,free iron and biliverdin.Emerging evidence suggests that HO-1,an inducible isoform of HO,can exert vaso-protective effects.However,such vascular benefit