药物敏感性试验在耐药结核病治疗中的效果分析

Effect analysis of drug sensitivity test in the treatment of drug-resistant tuberculosis

目的分析药物敏感性试验在耐药结核病治疗中的应用效果。方法选取天津市滨海新区塘沽结核病防治所2016年1-12月收治的60例耐药结核病患者作为研究对象,随机分为对照组和观察组各30例。对照组耐药结核病患者采用常规治疗方式,观察组耐药结核病患者根据药物敏感性试验结果制订相应的治疗方案。观察不同药物的敏感性试验结果以及两组患者的痰液转阴率。结果莫西沙星的药物敏感性最高,对氨基水杨酸的耐药敏感性次之,异烟肼的药物敏感性最低;观察组患者的痰液转阴率为93.3%,对照组患者的痰液转阴率为76.7%,差异有统计学意义(P<0.05)。结论在耐药结核病治疗中采用药物敏感性试验有助于提高治疗有效率,效果明显。

Objective To analyze the effect of drug sensitivity test in the treatment of drug-resistant tuberculosis.Methods 60 patients with drug-resistant tuberculosis admitted to Tanggu Tuberculosis Control Institute,Binhai New Area from January 2016 to December 2016 were selected and randomly divided into control group and observation group,with 30 cases in each group.Patients in control group were treated with routine treatment,and patients in observation group were treated according to drug sensitivity test results.The sensitivity test results of different drugs and the negative conversion rate of sputum in the two groups were observed.Results Moxifloxacin had the highest sensitivity,followed by aminosalicylic acid and isoniazid had the lowest drug sensitivity.The sputum negative conversion rate was 93.3%in the observation group and 76.7%in the control group.The differences were statistically significant(P<0.05).Conclusion The drug sensitivity test in the treatment of drug-resistant tuberculosis is helpful to improve the treatment efficiency,the effect is remarkable.