巴西人参化学成分的研究

Chemical constituents from Pfaffia paniculata

目的研究引种的巴西人参Pfaffia paniculata根中的化学成分。方法采用色谱分离技术进行分离和纯化,并根据谱学数据鉴定化合物的结构。结果从引种的巴西人参根部的甲醇提取物中分离得到14个化合物,包括11个30-降齐墩果烷型三萜和3个蜕皮激素类物质,分别鉴定为pfaffianol A(1)、3-oxo-akebonoic acid(2)、16β-hydroxyl-3-oxo-akebonoic acid(3)、pfaffiaglycoside A(4)、pfameric acid(5)、2α,3β,20α-trihydroxy-30-norolean-12-en-28-oic acid(6)、2α,3β-dihydroxy-23-oxo-30-norolean-12,20(29)-dien-28-oicacid(7)、2α,3β-dihydroxy-30-norolean-12,20(29)-dien-28-oicacid(8)、2α,3α-dihydroxy-30-norolean-12,20(29)-dien-28-oicacid(9)、木通种酸(10)、3β-hydroxy-30-norhederagenin(11)、diaulusterolB(12)、20,22-didehydrotaxisterone(13)和蜕皮甾酮(14)。结论化合物10～12为首次从巴西人参中分离得到,化合物6～9和13为首次从法菲亚属植物中分离得到。

Objective To study the chemical constituents from the roots of Pfaffia paniculata. Methods The compounds were isolated and purified by means of chromatographic separation techniques and their structures were identified based on spectral features. Results Fourteen known compounds, including 11 30-noroleanane triterpenoids and three ecdysterones, named pfaffianol A(1), 3-oxo-akebonoic acid(2), 16β-hydroxyl-3-oxo-akebonoic acid(3), pfaffiaglycoside A(4), pfameric acid(5), 2α,3β,20α-trihydroxy-30-norolean-12-en-28-oic acid(6), 2α,3β-dihydroxy-23-oxo-30-norolean-12,20(29)-dien-28-oic acid(7), 2α,3β-dihydroxy-30-norolean-12,20(29)-dien-28-oic acid(8), 2α,3α-dihydroxy-30-norolean-12,20(29)-dien-28-oic acid(9), quinatic acid(10), 3β-hydroxy-30-norhederagenin(11), diaulusterol B(12), 20,22-didehydrotaxisterone(13), and ecdysterone(14) were isolated from the roots of P. paniculata. Conclusion Compounds 10—12 are obtained from P. paniculata for the first time. Compounds 6—9, and 13 are isolated from the genus of Pfaffia for the first time.