阿魏酸钠的心脑血管药理作用研究进展

Pharmacological research progress of sodium ferulate in cardio-cerebral vascular disease

阿魏酸钠是传统活血化瘀中药当归和川芎提取物中主要活性成分阿魏酸的钠盐,来源非常丰富,具有多种药理活性,且不良反应少、安全性高,于1990年首次被批准用于临床,是我国完全自主研发的心脑血管药物。阿魏酸钠在心脑血管疾病方面具有广泛的效用,在治疗呼吸系统疾病、糖尿病及其并发症,保护肝脏、肾脏等方面也较为有效。对近30年来阿魏酸钠在心血管疾病方面的药理作用及研究现状进行综述,重点阐述其在抗血栓、抑制血小板聚集、血管保护及抗氧化等方面的作用,以期为阿魏酸钠的临床应用提供理论依据。

Sodium ferulate is the sodium salt of ferulic acid, an extract of traditional Chinese herbal medicines for promoting blood circulation and detoxification, and it is rich in sources, with few side effects and high safety. Sodium ferulate has many pharmacological effects, which is a cardiovascular drug researched and developed independently in China. It was first approved in 1990 for the clinical treatment of cardiovascular diseases. In recent years, the clinical application of sodium ferulate has become increasingly widespread, and the research field is continuously expanding. Sodium ferulate is effective in treating respiratory diseases, diabetes and complications, and protecting the liver and kidney from damage. Meanwhile it has been widely used in cardiovascular diseases. Here we reviewed the research status of the prominent pharmacological effects of sodium ferulate on cardiovascular diseases in the past 30 years, mainly focusing on the antithrombotic effects, the protection of blood vessels, and the anti-oxidative effect of sodium ferulate. It is expected to provide guidance for clinical applications of sodium ferulate.